Preparation of Substituted Tetrahydro-1-benzazepines by Lithiation-Trapping
نویسندگان
چکیده
منابع مشابه
Asymmetric synthesis of 3-substituted tetrahydro-2-benzazepines.
The enantiomerically and diastereomerically pure tricyclic oxazolidine cis-10 was prepared in a five step synthesis starting with 1-bromo-2-iodobenzene. Me3SiCN and allylSiMe3 reacted with cis-10 in the presence of TiCl4 to form the nitrile (3S)-11 and the allyl derivative (3S)-12 with high diastereoselectivity. The hydrogenolytic removal of the chiral auxiliary failed, since the endocyclic ben...
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2018
ISSN: 1434-193X
DOI: 10.1002/ejoc.201800868